Cellular Ageing and Replicative Senescence

Preface Section I History and originsChapter 1: Origins of the Hayflick system, the phenomenon and the limit. (an interview by Suresh I.S. Rattan) Chapter 2: Experimental foundations of the Hayflick system. (an interview by Suresh I.S. Rattan) Section II Serial passaging and progressive changesChapter 3: Slowing down of the cell cycle during fibroblast proliferation. by: Alvaro Macieira-Coelho Chapter 4: Influence of donor age and species longevity on replicative cellular senescence. by: Lorenzini and Andrea B. Maier Chapter 5: Ageing of the stem cells: the conjoined twosome growing old -stem cell and its niche. by: Günter Lepperdinger Chapter 6: Ageing and senescence in immune cells in vitro and in vivo. by: Graham Pawelec and Yvonne Barnett Chapter 7: Telomere shortening - a mere replicometer? by: Stella Victorelli and Joao Passos Chapter 8: Modelling cellular ageing: mathematical and computational approaches. by: Tarynn M. Witten Section III AGEING, CANCER and senescenceChapter 9: Cell cycle checkpoints and senescence. by: Renu Wadhwa, Zeenia Kaul and Sunil C. Kaul Chapter 10: Mitochondrial reactive oxygen species in cellular senescence. by: Timothy Nacarelli, Claudio Torres and Christian Sell Chapter 11: Cellular aging and tumour regulation. by: Andreas Simm, Barbara Seliger and Lars-Oliver Klotz Chapter 12: Biomarkers of replicative senescence revisited. by: Jan Nehlin Section IV AGEING ModulatORSChapter 13: Stress-induced (premature) senescence. by: Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaireand Olivier Toussaint Chapter 14: Implications of cellular senescence on aging and disease in the brain. by: Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D'Agostino, Christian Sell and Claudio Torres Chapter 15: Small non coding RNAs in senescence and aging. by: Joseph Dhahbi Chapter 16: Targeting senescent cells to improve huan health by: Tobias Wijshake and Jan M. A. van Deursen Section V RECAPITULATION AND FUTURE EXPECTATIONSChapter 17: Unlike the stochastic events that determine ageing, sex determines longevity. by: Leonard Hayflick Index... Mehr