Formulation and Evaluation of Olmesartan Medoxomil Dry Emulsion

In this book, the dry emulsion of Olmesartan medoxomil is prepared by spray drying method to improve the dissolution of poorly water soluble drug. Olmesartan medoxomil is a poorly soluble drug useful in the treatment of hypertension, absorption window of drug is stomach and upper part of small intestine.Dry emulsions can be prepared by spray drying, lyophilization and rotary evaporation. Dry emulsion was prepared by using castor oil in which drug is highly soluble, poloxamer188 as water soluble carrier and aerosil 200 as an adsorbent. The preferred oil was castor oil, olive oil, soybean oil and isopropyle myristate and polymers was PEG400, Eudragit EPO and Poloxamer 188. Stable milky formulation was formed by using surfactant (Tween 80 and span 80). Dry emulsion was evaluated for drug content, percentage moisture content, solubility. They were characterized by particle size determination, Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (PXRD) and Scanning Electron Microscopy (SEM) of drug.This study revealed that solid dry emulsion technique was proved to be promising and useful for improvement of solubility of antihypertensive drug.... Mehr