Systems Biology of Alzheimer's Disease

Part I: Systems Biology of Multifactorial Diseases: Alzheimer's Disease 1. Alzheimer's as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks Juan I. Castrillo and Stephen G. Oliver 2. Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease Simone Lista, Zaven S. Khachaturian, Dan Rujescu, Francesco Garaci, Bruno Dubois, and Harald Hampel Part II: Alzheimer's Disease: Main Underlying Pathways and Networks 3. The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease Sally Hunter, Steven Martin, and Carol Brayne 4. Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing Jiangli Tan, Qiao-Xin Li, and Genevieve Evin 5. Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models Ana García-Osta and Mar Cuadrado-Tejedor 6. Advanced Optical Super-Resolution Method and Techniques for the Study of beta-Amyloid Aggregation In Vitro and In Vivo Dorothea Pinotsi, Gabriele S. Kaminski Schierle, and Clemens F. Kaminski 7. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez, Miguel Medina, Javier DeFelipe, and Jesús Avila 8. LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells Anne Streeter, Fiona M. Menzies, and David C. Rubinsztein 9. Advanced Mitochondrial Respiration Assay for Evaluation of Mitochondrial Dysfunction in Alzheimer's Disease Amandine Grimm, Karen Schmitt, and Anne Eckert 10. Analysis of Microglial Proliferation in Alzheimer's Disease Diego Gomez-Nicola and V. Hugh Perry Part III: Comprehensive Disease Models Recapitulating Alzheimer's Disease Features: From Cellular Models to Human 11. Yeast as a Model for Alzheimer's Disease: Latest Studies and Advanced Strategies Mathias Verduyckt, Hélène Vignaud, Tine Bynens, Jeff Van den Brande, Vanessa Franssens, Christophe Cullin, and Joris Winderickx 12. Yeast as a Model for Studies on Abeta Aggregation Toxicity in Alzheimer's Disease, Autophagic Responses, and Drug Screening Afsaneh Porzoor and Ian Macreadie 13. Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease Jung Yeon Lim, Stanislav Ott, and Damian C. Crowther 14. Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models Mar Cuadrado-Tejedor and Ana García-Osta 15. Gene Expression Studies on Human Trisomy 21 iPSCs and Neurons: Towards Mechanisms Underlying Down's Syndrome and Early Alzheimer's Disease-Like Pathologies Jason P. Weick, Huining Kang, George F. Bonadurer III, and Anita Bhattacharyya 16. Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease Nathalie G. Saurat, Frederick J. Livesey, and Steven Moore Part IV: Experimental Systems Biology: Next Generation Molecular and High-Throughput Methods for the Study of Disease Susceptibility and Networks Dynamics Interplay in Complex Diseases 17. Next Generation Sequencing in Alzheimer's Disease Lars Bertram 18. Pooled-DNA Sequencing for Elucidating New Genomic Risk Factors, Rare Variants Underlying Alzheimer's Disease Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, and Carlos Cruchaga 19. New Genome-Wide Methods for Elucidation of Candidate Copy Number Variations (CNVs) Contributing to Alzheimer's Disease Heritability Kinga Szigeti 20. RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer's Disease Bei Jun Chen, James D. Mills, Caroline Janitz, and Michael Janitz 21. Systems Biology Approaches to the Study of Biological Networks Underlying Alzheimer's Disease: Role of miRNAs Wera Roth, David Hecker, and Eugenio Fava 22. The Emerging Role of Metalloproteomics in Alzheimer's Disease Research Dominic J. Hare, Alan Rembach, and Blaine R. Roberts 23. Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation Fabio Di Domenico, Marzia Perluigi, and D. Allan Butterfield 24. Advanced Shotgun Lipidomics for Characterization of Altered Lipid Patterns in Neurodegenerative Diseases and Brain Injury Miao Wang and Xianlin Han 25. AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis Soichi Ogishima, Satoru Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka, and Jun Nakaya Part V: Computational Systems Biology, Network biology: Next Generation Computational and Integrative Network Biology Approaches for the Study of Modules, Network Dynamics, and Their Interplay in Complex Diseases 26. A Computational Network Biology Approach to Uncover Novel Genes Related to Alzheimer's Disease Andreas Zanzoni 27. Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans Justin Yerbury, Dan Bean, and Giorgio Favrin 28. Characterization of Genetic Networks Associated with Alzheimer's Disease Bin Zhang, Linh Tran, Valur Emilsson, and Jun Zhu 29. Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer's Disease Masataka Kikuchi, Soichi Ogishima, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya, and Hiroshi Tanaka 30. The SDREM Method for Reconstructing Signaling and Regulatory Response Networks: Applications for Studying Disease Progression Anthony Gitter and Ziv Bar-Joseph Part VI: Systems Biology of Alzheimer's Disease in Practice: From Systems Biology to Early Diagnostics and Systems Medicine 31. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer's Disease Jorge Sepulcre and Joseph C. Masdeu 32. Plasma Proteomics Biomarkers in Alzheimer's Disease: Latest Advances and Challenges Robert Perneczky and Liang-Hao Guo 33. A Practical Guide For Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology Hongkang Mei, Gang Feng, Jason Zhu, Simon Lin, Yang Qiu, Yue Wang, and Tian Xia... Mehr